• 0.1µm AseptiSure HS Mini 2.5", 5"

0.1µm AseptiSure HS Mini 2.5", 5"

mdi AseptiSure HS PES membrane cartridge filters are high temperature resistant filtration devices, validated for Mycoplasma removal. These are designed to withstand high pressure differential at high temperature steam sterilization upto 135°C.

AseptiSure HS is a serial layered membrane filter with a larger pore size upstream layer to protect the final layer for enhanced throughputs.

These are validated for key performance parameters such as retention efficiency, chemical compatibility, extractables, heat stability and flow rates.

  • High heat Stability
  • Non-toxic material of construction
  • Heat sealed, no glues or adhesives
  • Each filter comes with an individual certificate of quality
Consistent and Reliable Quality: AseptiSure cartridge filters are produced with ISO 9001-2008 certified quality management systems.
Regulatory Compliance:
Meet all pharmacopeial and compendia requirements and are registered with USFDA DMF #015554
Low Protein Binding:
Results in increased overall product yield and higher throughputs with biological streams
High Throughputs:
Translates to lower filtration costs, less number of filter changes and overall economy of operations.
Total Traceability
Unique identification number is laser etched on each other.
  • Sterile Filtration of Culture media for mammalian cell culture
Membrane Polyethersulfone
Final Filter Pore Size 0.1µm
Prefilter Pore Size
0.2 µm0.45 µm
Support Layers Polyester
Body and Core Polypropylene
Integrity Testing / Retention
Bubble Point > 31psi (2.18Kg/cm²) with 50% IPA/Water Solution
Microbial Retention LRV >7 for Acholeplasma laidlawii (ATCC 23206) per cm²
2.5" 5"
Effective Filtration Area (Nominal)
1000cm² 2000cm²
Max. Operating Temperature 80 °C @ < 2 Kg/cm² (30 psi)
Max. Differential Pressure 3.5 Kg/cm² (50 psi) @ 25 °C
Reverse Pressure < 0.7 Kg/cm² (10 psi) @ 25 °C
Typical Water Flow Rates (10" Cartridge filters)
4.5 lpm @ 10 psi8 lpm @ 10 psi
Sterilization Autoclavable/In-line steam sterilizable at 135 °C for 30 minutes, 25 cycles @ Δp= 5psi (0.3kg/cm²)
Toxicity Passes Bioreactivity test, In Vivo, as per USP <88> for Class VI plastics
Cytotoxicity Passes Biological Reactivity Tests, In Vitro, USP <87> for cytotoxicity
Bacterial Endotoxin Aqueous extracts exhibit < 0.25 EU/ml as established by Limulus Amebocyte Lysate (LAL) Test
Non Fiber Releasing Passes test as per USP and comply with USFDA 21 CFR Part 210.3(b)(6) for fiber release
TOC and Conductivity Meets the WFI requirements of USP <643> for Total Organic Carbon and USP <645> for Water Conductivity after a specified volume of purified water flush
Particle Release The filtrate complies with USP <788> test for particulate matter in injections
Indirect Food Additive All Polypropylene components meet the FDA Indirect Food Additive requirements cited in 21 CFR 177.1520
Extractables with WFI Passes test as per USP
Good Manufacturing Practice These products are manufactured in a facility which adheres to Good Manufacturing Practices.
Oxidizable Substances Within limits as specified in USP
Quality Management System ISO-9001 Certified
USFDA DMF No. 015554
AseptiSure HS Mini
(0.45µm upstream)
AseptiSure HS Mini
(0.2µm upstream)
Size Code
2.5" 50
5" 53
Pore Size
Pore Size
0.1µm 36
4463 E0
4463B H0
4440 U0
Silicone SS
Non Sterile 1
Pack Size
Pack Size Code
1 01

*G0 adapter code is not available with any elastomer. Please mention XX in place of elastomer code while ordering

**Adapter Code F0 is available only in 5” cartidge filters

     Example :

CPHX 50 36 E0 SS 1 01
Example for Non Sterile: CPHX5036E0SS101
Datasheet Download

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