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AseptiMix™ MI Mini: Compact Single-Use Mixer Systems for Biopharmaceutical Applications

Biopharmaceutical processing involves a wide range of process fluids, with many critical mixing operations required within isolators. Applications such as vaccines with adjuvants, nano suspensions, and small batches of high-value drug products require reliable mixing solutions, particularly where process integrity, sterility, endotoxins, biosafety, extractables, and particle or fiber release are important considerations.

The MDI AseptiMix™ MI Mini has been specially designed to provide a validated and reliable single-use mixing solution for these requirements. These disposable, pre-sterilized mini mixer systems are designed for very small volumes starting from 400 mL.

The system uses a magnetic drive to rotate an impeller fixed inside the mixer bag, providing the mixing action without requiring direct mechanical contact with the impeller. The mixer bag is also available with a sanitary flange powder port for powder-to-liquid mixing.

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AseptiLink™ ST: Enhancing Sterile Fluid Transfer with Steam-Through Connector Technology

The biopharmaceutical industry is rapidly adopting single-use technologies (SUTs) to improve manufacturing flexibility, reduce cleaning requirements, and minimize the risk of cross-contamination. However, it may not be possible for all production facilities to shift over completely to SUTs and they continue to rely on stainless steel (SS) vessels, reactors, and hard-piped process lines for critical operations. Creating a sterile, validated interface between SUTs and SS systems has become an essential requirement for modern bioprocessing.

This is where steam-through connectors play a vital role.

The MDI AseptiLink™ ST Steam Through Connector has been specifically designed to establish a safe, secure, and validated sterile connection between steamable stainless steel processing equipment and gamma-sterilized disposable flow paths used in single-use assemblies.

Rather than replacing existing infrastructure, it enables manufacturers to integrate disposable technologies into existing processing facilities while maintaining sterility and improving operational flexibility.

Why Steam-Through Connections Matter

Sterile fluid transfer is one of the most critical operations in pharmaceutical and biopharmaceutical manufacturing. Whether transferring culture media, buffer solutions, process intermediates, or final product formulations, every connection point represents a potential contamination risk.

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